Swertiamarin: An Active Lead from Enicostemma littorale Regulates Hepatic and Adipose Tissue Gene Expression by Targeting PPAR-γ and Improves Insulin Sensitivity in Experimental NIDDM Rat Model
Figure 8
(a) Effect of EL extract and SM treatments on the mRNA expression of SREBP-1c, PPAR-γ, leptin, LPL, adiponectin, Glut 4, and β-actin in the adipose tissue as compared to diabetic rats. (Gel image). (b) Effect of EL extract and SM treatments on the expression of the major genes regulating the fat metabolism in the adipocytes as compared to diabetic rats. The expression levels were checked using semi-quantitative RT-PCR and densitometric analysis. Data presented as Mean ± SEM of 4 independent observations. ## versus control rats; ** versus diabetic rates. (c) Effect of EL extract and SM treatments on the expression of Glut 4 in the adipocytes as compared to diabetic rats. The expression levels were checked using semi-quantitative RT-PCR and densitometric analysis. Data presented as mean ± SEM of 4 independent observations. ## versus control rats; ** versus diabetic rates; value ns versus diabetic rats.
