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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 368103, 13 pages
http://dx.doi.org/10.1155/2013/368103
Research Article

MAPK Signal Transduction Pathway Regulation: A Novel Mechanism of Rat HSC-T6 Cell Apoptosis Induced by FUZHENGHUAYU Tablet

1Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
2Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China
3Department of Traditional Chinese Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
4Beijing Center for Physical and Chemical Analysis, Beijing 100094, China

Received 26 November 2012; Revised 9 April 2013; Accepted 9 April 2013

Academic Editor: Shao Li

Copyright © 2013 Qi Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Lazo and J. M. Clark, “The epidemiology of nonalcoholic fatty liver disease: a global perspective,” Seminars in Liver Disease, vol. 28, no. 4, pp. 339–350, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. C. D. Williams, J. Stengel, M. I. Asike et al., “Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study,” Gastroenterology, vol. 140, no. 1, pp. 124–131, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. S. L. Friedman, “Liver fibrosis: from bench to bedside,” Journal of Hepatology, vol. 38, supplement 1, pp. S38–S53, 2003. View at Scopus
  4. R. C. Benyon and J. P. Iredale, “Is liver fibrosis reversible?” Gut, vol. 46, no. 4, pp. 443–446, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. R. Bataller and D. A. Brenner, “Liver fibrosis,” Journal of Clinical Investigation, vol. 115, no. 2, pp. 209–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Marra, “Hepatic stellate cells and the regulation of liver inflammation,” Journal of Hepatology, vol. 31, no. 6, pp. 1120–1130, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Milani, H. Herbst, D. Schuppan, K. Y. Kim, E. O. Riecken, and H. Stein, “Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis,” Gastroenterology, vol. 98, no. 1, pp. 175–184, 1990. View at Scopus
  8. Y. He, C. Huang, S. P. Zhang, X. Sun, X. R. Long, and J. Li, “The potential of microRNAs in liver fibrosis,” Cellular Signalling, vol. 24, no. 12, pp. 2268–2272, 2012.
  9. Y. Inagaki and I. Okazaki, “Emerging insights into transforming growth factor β Smad signal in hepatic fibrogenesis,” Gut, vol. 56, no. 2, pp. 284–292, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Akpolat, S. Yahsi, A. Godekmerdan, M. Yalniz, and K. Demirbag, “The value of α-SMA in the evaluation of hepatic fibrosis severity in hepatitis B infection and cirrhosis development: a histopathological and immunohistochemical study,” Histopathology, vol. 47, no. 3, pp. 276–280, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Sekiya, T. Ogawa, K. Yoshizato, K. Ikeda, and N. Kawada, “Suppression of hepatic stellate cell activation by microRNA-29b,” Biochemical and Biophysical Research Communications, vol. 412, no. 1, pp. 74–79, 2011.
  12. Y. Murakami, H. Toyoda, M. Tanaka et al., “The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families,” PLoS ONE, vol. 6, no. 1, Article ID e16081, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Shu, B. T. Kren, Z. Xia et al., “Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration,” Hepatology, vol. 54, no. 2, pp. 609–619, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. C. J. Guo, Q. Pan, T. Cheng, B. Jiang, G. Y. Chen, and D. G. Li, “Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways,” FEBS Journal, vol. 276, no. 18, pp. 5163–5176, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Ideker and R. Sharan, “Protein networks in disease,” Genome Research, vol. 18, no. 4, pp. 644–652, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. B. S. Sanodiya, G. S. Thakur, R. K. Baghel, G. B. K. S. Prasad, and P. S. Bisen, “Ganoderma lucidum: a potent pharmacological macrofungus,” Current Pharmaceutical Biotechnology, vol. 10, no. 8, pp. 717–742, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Tang, Y. Liao, N. Kawaguchi-Sakita et al., “Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats,” Journal of Hepato-Biliary-Pancreatic Sciences, vol. 18, no. 4, pp. 551–558, 2011.
  18. C. C. Cheng, N. N. Lin, Y. F. Lee et al., “Effects of Shugan-Huayu powder, a traditional Chinese medicine, on hepatic fibrosis in rat model,” Chinese Journal of Physiology, vol. 53, no. 4, pp. 223–233, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. K. F. Cheung, D. W. Ye, Z. F. Yang et al., “Therapeutic efficacy of Traditional Chinese Medicine 319 recipe on hepatic fibrosis induced by carbon tetrachloride in rats,” Journal of Ethnopharmacology, vol. 124, no. 1, pp. 142–150, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Liu, Y. Y. Hu, C. Liu et al., “Multicenter clinical study on Fuzhenghuayu capsule against liver fibrosis due to chronic hepatitis B,” World Journal of Gastroenterology, vol. 11, no. 19, pp. 2892–2899, 2005. View at Scopus
  21. P. Liu, C. Liu, L. M. Xu et al., “Effects of Fuzheng Huayu 319 recipe on liver fibrosis in chronic hepatitis B,” World Journal of Gastroenterology, vol. 4, no. 1–6, pp. 348–353, 1998. View at Scopus
  22. C. Liu, C. M. Jiang, C. H. Liu, P. Liu, and Y. Y. Hu, “Effect for Fuzhenghuayu decoction on vascular endothelial growth factor secretion in hepatic stellate cells,” Hepatobiliary and Pancreatic Diseases International, vol. 1, no. 2, pp. 207–210, 2002. View at Scopus
  23. E. Borkham-Kamphorst, J. Herrmann, D. Stoll, J. Treptau, A. M. Gressner, and R. Weiskirchen, “Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis,” Laboratory Investigation, vol. 84, no. 6, pp. 766–777, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. J. B. Chakraborty, F. Oakley, and M. J. Walsh, “Mechanisms and biomarkers of apoptosis in liver disease and fibrosis,” International Journal of Hepatology, vol. 2012, Article ID 648915, 10 pages, 2012. View at Publisher · View at Google Scholar
  25. S. L. Friedman, “Evolving challenges in hepatic fibrosis,” Nature Reviews Gastroenterology and Hepatology, vol. 7, no. 8, pp. 425–436, 2010.
  26. F. Xiao, K. Yu, F. Dong, Y. Liang, C. Jun, and H. Wei, “The GABAB receptor inhibits activation of hepatic stellate cells,” Digestive Diseases and Sciences, vol. 55, no. 2, pp. 261–267, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Min, B. He, and L. Hui, “Mitogen-activated protein kinases in hepatocellular carcinoma development,” Seminars in Cancer Biology, vol. 21, no. 1, pp. 10–20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Santarpia, S. M. Lippman, and A. K. El-Naggar, “Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy,” Expert Opinion on Therapeutic Targets, vol. 16, no. 1, pp. 103–119, 2012.
  29. H. J. Schaeffer and M. J. Weber, “Mitogen-activated protein kinases: specific messages from ubiquitous messengers,” Molecular and Cellular Biology, vol. 19, no. 4, pp. 2435–2444, 1999. View at Scopus
  30. S. Li, “Network systems underlying traditional Chinese medicine syndrome and herb formula,” Current Bioinformatics, vol. 4, no. 3, pp. 188–196, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Wu, R. Jiang, M. Q. Zhang, and S. Li, “Network-based global inference of human disease genes,” Molecular Systems Biology, vol. 4, article 189, 2008.
  32. S. Li, L. Wu, and Z. Zhang, “Constructing biological networks through combined literature mining and microarray analysis: a LMMA approach,” Bioinformatics, vol. 22, no. 17, pp. 2143–2150, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. E. Albanis and S. L. Friedman, “Hepatic fibrosis: pathogenesis and principles of therapy,” Clinics in Liver Disease, vol. 5, no. 2, pp. 315–334, 2001. View at Scopus
  34. B. Schnabl, C. A. Bradham, B. L. Bennett, A. M. Manning, B. Stefanovic, and D. A. Brenner, “TAK1/JNK and p38 have opposite effects on rat hepatic stellate Cells,” Hepatology, vol. 34, no. 5, pp. 953–963, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. E. Chan, D. E. Prado, and J. B. Weidhaas, “Cancer microRNAs: from subtype profiling to predictors of response to therapy,” Trends in Molecular Medicine, vol. 17, no. 5, pp. 235–243, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. L. A. Goff, S. Boucher, C. L. Ricupero et al., “Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis,” Experimental Hematology, vol. 36, no. 10, pp. 1354–1369, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. C. J. Guo, Q. Pan, D. G. Li, H. Sun, and B. W. Liu, “miR-15b and miR-16 are implicated in activation of the rat hepatic stellate cell: an essential role for apoptosis,” Journal of Hepatology, vol. 50, no. 4, pp. 766–778, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. R. M. O'Connell, D. S. Rao, A. A. Chaudhuri, and D. Baltimore, “Physiological and pathological roles for microRNAs in the immune system,” Nature Reviews Immunology, vol. 10, no. 2, pp. 111–122, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. X. W. Wang, N. H. H. Heegaard, and H. Orum, “MicroRNAs in liver disease,” Gastroenterology, vol. 142, no. 7, pp. 1431–1414, 2012.
  40. C. Roderburg, G. W. Urban, K. Bettermann et al., “Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis,” Hepatology, vol. 53, no. 1, pp. 209–218, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Asselah, I. Bièche, A. Sabbagh et al., “Gene expression and hepatitis C virus infection,” Gut, vol. 58, no. 6, pp. 846–858, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. F. Marra, M. C. Arrighi, M. Fazi et al., “Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat,” Hepatology, vol. 30, no. 4, pp. 951–958, 1999. View at Publisher · View at Google Scholar · View at Scopus
  43. N. M. Jameel, C. Thirunavukkarasu, W. U. Tong, S. C. Watkins, S. L. Friedman, and C. R. Gandhi, “P38-MAPK-and caspase-3- mediated superoxide-induced apoptosis of rat hepatic stellate cells: reversal by retinoic acid,” Journal of Cellular Physiology, vol. 218, no. 1, pp. 157–166, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. R. F. Schwabe, B. Schnabl, Y. O. Kweon, and D. A. Brenner, “CD40 activates NF-κB and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells,” Journal of Immunology, vol. 166, no. 11, pp. 6812–6819, 2001. View at Scopus
  45. R. F. Schwabe, H. Uchinami, T. Qian, B. L. Bennett, J. J. Lemasters, and D. A. Brenner, “Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes,” The FASEB journal, vol. 18, no. 6, pp. 720–722, 2004. View at Scopus
  46. J. Ping, J. T. Li, Z. X. Liao, L. Shang, and H. Wang, “Indole-3-carbinol inhibits hepatic stellate cells proliferation by blocking NADPH oxidase/reactive oxygen species/p38 MAPK pathway,” European Journal of Pharmacology, vol. 650, no. 2-3, pp. 656–662, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. Y. Wang, J. Kellner, L. Liu, and D. Zhou, “Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion,” Stem Cells and Development, vol. 20, no. 7, pp. 1143–1152, 2011. View at Publisher · View at Google Scholar · View at Scopus