An Engineered Arginase FC Protein Inhibits Tumor Growth In Vitro and In Vivo

Figure 4

rhArg-Fc induces tumor cell arresting at S-phase. Huh7 cells were incubated with rhArg-Fc at different concentration for 2 days. Cell DNA content were analyzed by flow cytometry as described in the Materials and Methods. rhArg-Fc treatment induced a dose-dependent increase in the proportion of cell in S-phase while causing a decrease in the G1 phase compare to control.