Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening

Figure 11

Effect of curcumin on cytochrome c (cyt c) release induced by the treatment with K₂Cr₂O₇. Liver mitochondria were incubated for 10 min with 50 μM Ca²⁺, in the presence or the absence of CsA. (a) Mitochondrial cyt c released and cyt c retained by Western blot analysis, (b) cyt c released/ANT ratio, and (c) cyt c retained/ANT ratio. Values are mean ± SEM, 𝑛=3. ^a𝑃<0.05versus control; ^b𝑃<0.05versus K₂Cr₂O₇ (24 h); ^c𝑃<0.05versus K₂Cr₂O₇ (48 h). ANT: adenine nucleotide translocator; CsA: cyclosporine A.

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