Research Article

Curcumin Pretreatment Prevents Potassium Dichromate-Induced Hepatotoxicity, Oxidative Stress, Decreased Respiratory Complex I Activity, and Membrane Permeability Transition Pore Opening

Table 1

Effect of curcumin pretreatment on K2Cr2O7-induced alterations in mitochondrial oxygen consumption using succinate as substrate.

ControlCURK2Cr2O7 (24 h)CUR-K2Cr2O7 (24 h)K2Cr2O7 (48 h)CUR-K2Cr2O7 (48 h)

Succinate
 State 3 (ngAtO/min/mg protein) a
 State 4 (ngAtO/min/mg protein)
 RCI
 Uncoupled respiration (ngAtO/min/mg protein) a
 ADP/O

Values are mean ± SEM, . CUR: curcumin; RCI: respiratory control index. versus control.