Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling

<table>HLXL reduces bone resorption and osteoclast numbers in arthritic rats. Bone histomorphometry was performed on TRAP-stained sections of hind paws of HLXL-treated versus Water-treated rats (<svg height="10.925" id="M11" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 10.925" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> per group). The measurements of the following parameters are shown in the figure: (a) bone volume versus total tissue volume (BV/TV); (b) the number of osteoclasts per tissue area (N.Oc/T.Ar); (c) active resorption per bone surface area based on the ratio of osteoclast surface/bone surface area (Oc.S/BS); and (d) the number of osteoclasts per bone perimeter (N.Oc/B.Pm). (*<svg height="11.375" id="M12" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, comparing experimental and control samples.)</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling 

Figure 2 | Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling 