Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling

<table>Inhibition of proinflammatory cytokines and MMP activity in HLXL-treated arthritic rats. Synovial-infiltrating cells (SIC) harvested on d 18 (peak phase of arthritis) from HLXL-fed or Water-fed rats (<svg height="11.075" id="M16" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.075" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> per group) were cultured for 24 h with or without sonicated Mtb. The levels of cytokines IL-18 and IL-1<i>β</i> (left panel) in culture supernatants were measured using a Multiplex assay and the results were expressed as pg/mL. MMP-9 and MMP-2 activity (right panel) was tested in the culture supernatants of Mtb-restimulated SIC cells of HLXL/Water-treated rats. Mtb: heat-killed <i>M. tuberculosis</i> H37Ra; Med: medium. (*<svg height="11.375" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, comparing experimental and control samples.)</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling 

Figure 4 | Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling 