Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling

<table>A schematic representation of the mechanisms involved in HLXL-induced suppression of bone damage in AA. HLXL suppressed bone damage via inhibiting the expression of osteoclastogenic mediators (receptor activator of nuclear factor kappa-B ligand: RANKL; granulocyte-macrophage colony-stimulating factor: GM-CSF; osteopontin: OPN; and insulin-like growth factor: IGF), cytokines (IL-18 and IL-1<i>β</i>), and matrix metalloproteinases (MMPs). (L: lymph node, I: inflamed joint, Mtb: heat-killed<i> Mycobacterium tuberculosis</i> H37Ra, osteoprotegerin: OPG.) Red arrows highlight increased amount/activity of the indicated mediators in arthritis, which are inhibited by HLXL treatment.</table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling 

Figure 5 | Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling 