Metabolomic Study of Collagen-Induced Arthritis in Rats and the Interventional Effects of Huang-Lian-Jie-Du-Tang, a Traditional Chinese Medicine

Table 1

Effects of HLJDT and its components on MDA levels and antioxidant enzymes’ activities on day 22.

Groups	MDA (nmol/mL)	SOD (U/mL)^a	GSH-Px (U/mL)^b
Normal control	2.71 ± 0.34	4.56 ± 0.24	7.72 ± 0.71
Model control	4.98 ± 0.53^##	2.95 ± 0.22^##	4.97 ± 1.56^#
Dexamethasone	2.62 ± 0.28**	4.23 ± 0.33**	7.69 ± 1.38*
HLJDT	2.99 ± 0.38**	4.74 ± 0.29**	7.30 ± 1.13*
Components of HLJDT	2.91 ± 0.42**	5.27 ± 0.22**	6.82 ± 0.91*

SOD: superoxide dismutase; GSH-Px: glutathione peroxidase. *P < 0.05, ^∗∗𝑃<0.01, ^#𝑃<0.05, and ^##𝑃<0.01 (^#: compared with normal control group; *: compared with model control group).
^aOne unit of SOD activity is defined as amount of SOD when SOD inhibition ratio reaches 50% in 1 mL reaction solution.
^bOne unit of GSH-Px activity is defined as amount of enzyme required to degrade 1 μmol/L of GSH per min subtracting nonenzymatic reaction at 37°C.