α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study

Table 2

Effects of α-mangostin (AM) of liver function tests (ALT and AST), gastric MDA, GSH, NP-SH and nitric oxide.

Animal groups	Pre-treatment; (5 mL/kg dose)	AST	ALT	GSH	MDA; (𝜇mol/g tissue)	NP-SH; (𝜇mol/g tissue)	Nitric oxide [NO2^−] 𝜇M
1	Tween80; (normal control)	61.06^a±1.1	145.06^a±1.8	1.6^a±0.03	14^b±0.31	0.6^a±0.09	9.2^a±0.19
2	Ethanol 95%; (ulcer control)	97^b±0.15	292.2^b±19.2	0.7^b±0.10	28^a±0.14	7.2^b±0.5	3.32^b±0.21
3	Omeprazole (20 mg/kg)	63^a±0.76	176^a±4.1	1.7^a±0.03	15^a±0.21	1.71^a±1.4	7.7^a±1.12
4	𝛼-mangostin (10 g/kg)	64^d±1.5	173^d±3.6	1.41^d±0.3	14^d±0.12	2.6^d±0.19	6.3^d±0.14
5	α-mangostin (30 mg/kg)	59^e±6.2	164^e±5.0	1.7^e±0.02	14^e±0.11	1.40^e±0.93	8.1^e±0.53

Values are presented as mean ± SEM of five rats in each group. Glutathione (GSH) levels, malondialdehyde level (MDA), nitric oxide (NO), alanine transaminase (ALT), aspartame transaminase (AST) and non-protein sulfhydryl groups (NP-SH) were measured in all groups. Groups with different alphabets are statistically different.