Effect of Formononetin on Mechanical Properties and Chemical Composition of Bones in Rats with Ovariectomy-Induced Osteoporosis

Table 2

Effects of estradiol and formononetin on bone macrometric parameters in ovariectomized rats.

Parameters	SHAM	OVX	OVX + ES	OVX + FRM
Femur
Mass/body mass (g/kg)	2.78 ± 0.08	2.5 ± 0.02^AA	2.65 ± 0.03^BB	2.61 ± 0.07
Length (mm)	35.5 ± 0.3	35.7 ± 0.3	35.7 ± 0.5	35.6 ± 0.2
Diameter (mm)	3.0 ± 0.05	2.84 ± 0.04	2.90 ± 0.05	2.94 ± 0.06
Tibia
Mass/body mass (g/kg)	2.02 ± 0.08	1.82 ± 0.03^A	1.89 ± 0.04	1.86 ± 0.02
Length (mm)	37.8 ± 0.6	38.0 ± 0.4	37.9 ± 0.5	38.2 ± 0.4
Diameter (mm)	2.29 ± 0.05	2.12 ± 0.01^A	2.20 ± 0.06	2.22 ± 0.05
L-4 vertebra
Mass/body mass (g/kg)	0.71 ± 0.04	0.61 ± 0.01	0.68 ± 0.02	0.67 ± 0.03

Results are presented as means ± SEM (𝑛=7). ^A𝑃<0.05, ^AA𝑃<0.01—statistically significant differences between the OVX and the SHAM groups; ^BB𝑃<0.01—statistically significant differences in comparison with the OVX group.