Effect of Formononetin on Mechanical Properties and Chemical Composition of Bones in Rats with Ovariectomy-Induced Osteoporosis
Table 3
Effects of estradiol and formononetin on bone mechanical properties in ovariectomized rats.
Parameter
SHAM
OVX
OVX + ES
OVX + FRM
Femoral diaphysis
Maximum load (N)
94.0 ± 3.6
88.2 ± 3.5
93.2 ± 5.6
92.1 ± 3.8
Displacement for maximum load (mm)
0.60 ± 0.02
0.65 ± 0.02
0.58 ± 0.01
0.62 ± 0.01
Fracture load (N)
93.9 ± 3.6
84.5 ± 6.0
94.0 ± 8.3
88.0 ± 3.8
Displacement for fracture load (mm)
0.61 ± 0.03
0.72 ± 0.07
0.60 ± 0.09
0.63 ± 0.03
Young’s modulus (MPa)
4673.9 ± 474.7
4386.7 ± 384.4
4933.7 ± 333.5
5352.2 ± 463.7
Tibial metaphysis
Maximum load (N)
114.9 ± 5.1
56.3 ± 7.9AAA
75.9 ± 10.0
67.4 ± 5.4
Displacement for maximum load (mm)
0.85 ± 0.07
0.86 ± 0.05
0.90 ± 0.07
0.91 ± 0.06
Fracture load (N)
110.7 ± 3.8
50.4 ± 9.9AAA
75.4 ± 9.9B
65.5 ± 4.9
Displacement for fracture load (mm)
1.01 ± 0.07
1.16 ± 0.27
1.06 ± 0.22
1.09 ± 0.02
Young’s modulus (MPa)
3318.2 ± 957.6
1628.3 ± 449.3A
1774.3 ± 492.3
1943.3 ± 228.3
Femoral neck
Maximum load (N)
93.2 ± 3.1
80.9 ± 6.2
90.2 ± 5.3
78.6 ± 4.8
Results are presented as means ± SEM (). A, AAA—statistically significant differences between the OVX and the SHAM groups; B—statistically significant differences in comparison with the OVX group.