PI3K/Akt Pathway Contributes to Neurovascular Unit Protection of Xiao-Xu-Ming Decoction against Focal Cerebral Ischemia and Reperfusion Injury in Rats
Figure 2
Cerebral infarct area and neurological deficits score at 24 h after reperfusion. (a) Representative images of brain slices stained with 1% TTC. The infarct area appeared white, whereas noninfarct areas were stained red purple. (b) Quantitative analysis of cerebral infarct areas. XXMD treatment reduced infarct area and LY294002 partially abolished the reduction in infarct area induced by XXMD treatment. (c) Effect of XXMD on neurological deficits score. XXMD treatment significantly improved neurological deficits score and LY294002 reversed effects of XXMD treatment. A, sham group; B, I/R group; C, XXMD60 group; D, XXMD60 + LY294002 group; E, XXMD60 + vehicle group; LY, LY294002. Data are reported as the means ± SEM. ; * versus the I/R group.
