PI3K/Akt Pathway Contributes to Neurovascular Unit Protection of Xiao-Xu-Ming Decoction against Focal Cerebral Ischemia and Reperfusion Injury in Rats
Figure 3
Representative images of Nissl staining and analysis of intact cells in different groups at 24 h after reperfusion. (a) The images of Nissl staining. Normal neurons were arranged orderly and had normal morphology with intact structure, abundant cytoplasm, and clear nucleolus in sham group. Most neurons in the damaged area appeared shrunken and deep stained in the I/R group. XXMD treatment improved the ischemic changes, which were blocked by LY294002. (b) Analysis of intact cells in penumbra of ischemic area. The number of intact cells in XXMD60 group was significantly higher than that in the I/R group. LY, LY294002. Scale bar = 50 μm. Data are reported as the means ± SEM. ; * versus the I/R group.
