Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit

Table 2

Effect of extract, fractions, and compounds isolated from H.  pectinata against promastigotes of L. braziliensis.

Treatment	IC50^a (concentration ± S.E.M.)	Maximum effect; (% ± S.E.M.)
Pentamidine	0.9±0.03 µM/0.3 ± 0.01 μg/mL	93.5±0.7^∗∗
EtOH extract	0.7±0.1 μg/mL	91.6±2.5^∗∗
MeOH : H2O fraction	3.9±1.5 μg/mL	61.5±1.2^∗∗
AcOEt fraction	0.4±0.1 μg/mL	81.5±5.9^∗∗
Hexane fraction	0.2±0.1 μg/mL	90.0±3.6^∗∗
1	6.9±0.7 μM/2.5±0.04 μg/mL	56.0±0.8^∗∗
2	>100 μM/>36.0 μg/mL	48.8±1.7^∗∗
3	>100 μM/>36.0 μg/mL	NA
4	5.4±0.8 μM/2.0±0.3 μg/mL	69.1±2.7^∗∗
5	>100 μM/>20.8 μg/mL	NA
7	>100 μM/>31.4 μg/mL	NA

Data are reported as the mean ± S.E.M. Differences with a *𝑃 value < 0.05 were considered significant relative to the 0.1% DMSO group.
^aIC₅₀ is the concentration required to give 50% mortality, calculated by linear regression analysis from the Kc values at the concentrations employed.
NA: the compound is not active.