Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction
Figure 7
Effects of WXKL and KN93 on the Ca transient amplitudes in ISO-stimulated cardiac myocytes. (a) Detailed tracings for 7 treatment groups. (b) The Ca transient amplitudes in ISO-stimulated cardiac myocytes (10−6 M ISO) were significantly increased compared with those in non-ISO-stimulated cells, but WXKL treatment (1 g/L, 5 g/L and 10 g/L) reduced the Ca transient amplitudes in a dose-dependent manner. Treatment with KN93 (1 mM) also significantly reduced the Ca transient amplitudes, while treatment with KN92 (1 mM) did not reduce them. (* versus the ISO group, ▲ versus the normal group).
