[Retracted] Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid 𝜷-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK

Figure 4

Effect of HO-1 expression on Aβ 25--35-induced oxidative neurotoxicity mediated by D in PC12 cells. (a) Cells were treated with 10 μM of D or 20 μM CoPP in the presence or absence of 50 μM ZnPP and then exposed to Aβ 25--35 (25 μM) for 24 h. (b) Exposure of PC12 cells to 25 μM Aβ 25--35 for 24 h increased ROS production. D-induced HO-1 effectively inhibited ROS production. Each bar represents mean ± SD from three experiments with triplicates. **𝑃<0.01 compared with control. ***𝑃<0.001 compared with control. ^##𝑃<0.01 compared with the group treated by Aβ 25--35 alone. ^###𝑃<0.001 compared with the group treated by Aβ 25--35 alone.

(a)  

(b)