In Vitro Global Gene Expression Analyses Support the Ethnopharmacological Use of Achyranthes aspera
Figure 4
Canonical pathway analyses in MetaCore tool identified Transcription assembly of RNA polymerase II preinitiation complex on TATA-less promoters to be the top scored pathway map () in LE treated cells. Red thermometers show an object that is upregulated by LE. Blue thermometer show the objects downregulated by LE. The exact fold change obtained from three time points with the corresponding SD is given in Table 2. The big arrow indicates the “pathway start.” TR: transcriptional regulation; CS: complex subunit; B: binding; grey arrow: technical link; green arrows: positive effect blue arrows represent positive, red negative, and grey unspecified interactions. Boxes on lines denote the type of regulation where P is phosphorylation, B is binding, and TR is transcriptional regulation. A detailed legend for the objects in this figure is given in the Supplementary File SF-1.
