- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 503521, 13 pages
6-Shogaol Protects against Oxidized LDL-Induced Endothelial Injruries by Inhibiting Oxidized LDL-Evoked LOX-1 Signaling
1Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Road, Shanghai 200120, China
2Department of Oncology, Shanghai Shidong Hospital, Shanghai 200438, China
3Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China
4Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China
5Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
Received 19 November 2012; Accepted 14 January 2013
Academic Editor: Muhammad Nabeel Ghayur
Copyright © 2013 Yun kai Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Y. Numaguchi, K. Naruse, M. Harada et al., “Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 19, no. 3, pp. 727–733, 1999.
- L. Zhang, P. Sivashanmugam, J. H. Wu et al., “Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 2, pp. 284–289, 2008.
- L. M. Cancel and J. M. Tarbell, “The role of apoptosis in LDL transport through cultured endothelial cell monolayers,” Atherosclerosis, vol. 208, no. 2, pp. 335–341, 2010.
- A. von Eckardstein and L. Rohrer, “Transendothelial lipoprotein transport and regulation of endothelial permeability and integrity by lipoproteins,” Current Opinion in Lipidology, vol. 20, no. 3, pp. 197–205, 2009.
- M. M. Kavurma, R. Bhindi, H. C. Lowe, C. Chesterman, and L. M. Khachigian, “Vessel wall apoptosis and atherosclerotic plaque instability,” Journal of Thrombosis and Haemostasis, vol. 3, no. 3, pp. 465–472, 2005.
- W. A. Hsueh and M. J. Quinones, “Role of endothelial dysfunction in insulin resistance,” The American Journal of Cardiology, vol. 92, pp. 10J–17J, 2003.
- T. Kamota, T. S. Li, N. Morikage et al., “Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase,” Journal of the American College of Cardiology, vol. 53, no. 19, pp. 1814–1822, 2009.
- R. Ross, “Atherosclerosis—an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999.
- D. Li and J. L. Mehta, “Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells,” Circulation, vol. 101, no. 25, pp. 2889–2895, 2000.
- J. Cheng, R. Cui, C. H. Chen, and J. Du, “Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells,” Endocrinology, vol. 148, no. 5, pp. 2085–2094, 2007.
- J. Lu, J. H. Yang, A. R. Burns et al., “Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis,” Circulation Research, vol. 104, no. 5, pp. 619–627, 2009.
- L. Zeng, A. Zampetaki, A. Margariti et al., “Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 20, pp. 8326–8331, 2009.
- J. Chen, J. L. Mehta, N. Haider, X. Zhang, J. Narula, and D. Li, “Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cells,” Circulation Research, vol. 94, no. 3, pp. 370–376, 2004.
- K. Ishiguro, T. Ando, O. Maeda et al., “Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms,” Biochemical and Biophysical Research Communications, vol. 362, no. 1, pp. 218–223, 2007.
- S. Dugasani, M. R. Pichika, V. D. Nadarajah, M. K. Balijepalli, S. Tandra, and J. N. Korlakunta, “Comparative antioxidant and anti-inflammatory effects of -gingerol, -gingerol, -gingerol and -shogaol,” Journal of Ethnopharmacology, vol. 127, no. 2, pp. 515–520, 2010.
- E. P. Sabina, M. Rasool, L. Mathew, P. EzilRani, and H. Indu, “6-shogaol inhibits monosodium urate crystal-induced inflammation—an in vivo and in vitro study,” Food and Chemical Toxicology, vol. 48, no. 1, pp. 229–235, 2010.
- M. H. Pan, M. C. Hsieh, P. C. Hsu et al., “6-shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages,” Molecular Nutrition and Food Research, vol. 52, no. 12, pp. 1467–1477, 2008.
- Y. Isa, Y. Miyakawa, M. Yanagisawa et al., “6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-α mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes,” Biochemical and Biophysical Research Communications, vol. 373, no. 3, pp. 429–434, 2008.
- H. Nie, L. Z. Meng, H. Zhang, J. Y. Zhang, Z. Yin, and X. S. Huang, “Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography,” Chinese Medical Journal, vol. 121, no. 13, pp. 1226–1229, 2008.
- M. N. Ghayur and A. H. Gilani, “Ginger lowers blood pressure through blockade of voltage-dependent calcium channels,” Journal of Cardiovascular Pharmacology, vol. 45, no. 1, pp. 74–80, 2005.
- M. N. Ghayur, A. H. Gilani, M. B. Afridi, and P. J. Houghton, “Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways,” Vascular Pharmacology, vol. 43, no. 4, pp. 234–241, 2005.
- B. Fuhrman, M. Rosenblat, T. Hayek, R. Coleman, and M. Aviram, “Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice,” Journal of Nutrition, vol. 130, no. 5, pp. 1124–1131, 2000.
- S. K. Verma, M. Singh, P. Jain, and A. Bordia, “Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits,” Indian Journal of Experimental Biology, vol. 42, no. 7, pp. 736–738, 2004.
- Y. K. Wang, Y. J. Hong, M. Wei et al., “Curculigoside attenuates human umbilical vein endothelial cell injury induced by H2O2,” Journal of Ethnopharmacology, vol. 132, no. 1, pp. 233–239, 2010.
- E. Mendis, M. M. Kim, N. Rajapakse, and S. K. Kim, “An in vitro cellular analysis of the radical scavenging efficacy of chitooligosaccharides,” Life Sciences, vol. 80, no. 23, pp. 2118–2127, 2007.
- E. C. Vaquero, M. Edderkaoui, S. J. Pandol, I. Gukovsky, and A. S. Gukovskaya, “Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells,” The Journal of Biological Chemistry, vol. 279, no. 33, pp. 34643–34654, 2004.
- H. Q. Wang, T. Quan, T. He, T. F. Franke, J. J. Voorhees, and G. J. Fisher, “Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes,” The Journal of Biological Chemistry, vol. 278, no. 46, pp. 45737–45745, 2003.
- M. Walton, E. Sirimanne, C. Reutelingsperger, C. Williams, P. Gluckman, and M. Dragunow, “Annexin V labels apoptotic neurons following hypoxia-ischemia,” NeuroReport, vol. 8, no. 18, pp. 3871–3875, 1997.
- Y. G. Cherng, H. C. Chang, Y. L. Lin, M. L. Kuo, W. T. Chiu, and R. M. Chen, “Apoptotic insults to human chondrocytes induced by sodium nitroprusside are involved in sequential events, including cytoskeletal remodeling, phosphorylation of mitogen-activated protein kinase kinase kinase-1/c-jun N-terminal kinase, and baxmitochondria-mediated caspase activation,” Journal of Orthopaedic Research, vol. 26, no. 7, pp. 1018–1026, 2008.
- J. Wölle, E. Ferguson, C. Keshava et al., “Inhibition of tumor necrosis factor induced human aortic endothelial cell adhesion molecule gene expression by an alkoxybenzo[b]thiophene-2-carboxamide,” Biochemical and Biophysical Research Communications, vol. 214, no. 1, pp. 6–10, 1995.
- S. B. Lotito and B. Frei, “Dietary flavonoids attenuate tumor necrosis factor α-induced adhesion molecule expression in human aortic endothelial cells: structure-function relationships and activity after first pass metabolism,” The Journal of Biological Chemistry, vol. 281, no. 48, pp. 37102–37110, 2006.
- G. Gloire, S. Legrand-Poels, and J. Piette, “NF-κB activation by reactive oxygen species: fifteen years later,” Biochemical Pharmacology, vol. 72, no. 11, pp. 1493–1505, 2006.
- X. P. Chen, T. T. Zhang, and G. H. Du, “Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?” Cardiovascular Drug Reviews, vol. 25, no. 2, pp. 146–161, 2007.
- J. Davignon and P. Ganz, “Role of endothelial dysfunction in atherosclerosis,” Circulation, vol. 109, no. 23, pp. I27–I32, 2004.
- C. Hu, A. Dandapat, L. Sun et al., “Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion,” Hypertension, vol. 52, no. 3, pp. 556–562, 2008.
- D. Y. Li, H. J. Chen, E. D. Staples et al., “Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 7, no. 3, pp. 147–153, 2002.
- J. L. Mehta, J. Chen, P. L. Hermonat, F. Romeo, and G. Novelli, “Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders,” Cardiovascular Research, vol. 69, no. 1, pp. 36–45, 2006.
- J. L. Mehta, N. Sanada, C. P. Hu et al., “Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet,” Circulation Research, vol. 100, no. 11, pp. 1634–1642, 2007.
- X. P. Chen, K. L. Xun, Q. Wu, T. T. Zhang, J. S. Shi, and G. H. Du, “Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species,” Vascular Pharmacology, vol. 47, no. 1, pp. 1–9, 2007.
- M. Nagase, K. Ando, T. Nagase, S. Kaname, T. Sawamura, and T. Fujita, “Redox-sensitive regulation of LOX-1 gene expression in vascular endothelium,” Biochemical and Biophysical Research Communications, vol. 281, no. 3, pp. 720–725, 2001.
- U. Rueckschloss, N. Duerrschmidt, and H. Morawietz, “NADPH oxidase in endothelial cells: impact on atherosclerosis,” Antioxidants and Redox Signaling, vol. 5, no. 2, pp. 171–180, 2003.
- S. J. Lin, S. K. Shyue, P. L. Liu et al., “Adenovirus-mediated overexpression of catalase attenuates oxLDL-induced apoptosis in human aortic endothelial cells via AP-1 and C-Jun N-terminal kinase/extracellular signal-regulated kinase mitogen-activated protein kinase pathways,” Journal of Molecular and Cellular Cardiology, vol. 36, no. 1, pp. 129–139, 2004.
- S. L. Jewett, A. M. Rocklin, M. Ghanevati, J. M. Abel, and J. A. Marach, “A new look at a time-worn system: oxidation of CuZn-SOD by H2O2,” Free Radical Biology and Medicine, vol. 26, no. 7-8, pp. 905–918, 1999.
- N. Kume and T. Kita, “Apoptosis of vascular cells by oxidized LDL: involvement of caspases and LOX-1 and its implication in atherosclerotic plaque rupture,” Circulation Research, vol. 94, no. 3, pp. 269–270, 2004.
- D. Li and J. L. Mehta, “Intracellular signaling of LOX-1 in endothelial cell apoptosis,” Circulation Research, vol. 104, no. 5, pp. 566–568, 2009.