Optimization on Preparation Condition of Propolis Flavonoids Liposome by Response Surface Methodology and Research of Its Immunoenhancement Activity

Table 3

Estimated regression model of relationship between response variables (EE) and independent variables (𝑋₁,𝑋₂, and  𝑋₃).

Source	Sun of squares	df	Mean square	𝐹  value	𝑃 value; prob > 𝐹
Model	700.32	9	77.81	75.33	<0.0001
A	6.66	1	6.66	6.45	0.0387
B	39.21	1	39.21	37.96	0.0005
C	6.612 × 10^−3	1	6.612 × 10^−3	6.402 × 10^−3	0.9385
AB	1.63	1	1.63	1.57	0.2499
AC	22.33	1	22.33	21.61	0.0023
BC	0.50	1	0.50	0.49	0.5073
𝐴^2	225.61	1	225.61	218.42	<0.0001
𝐵^2	99.76	1	99.76	96.58	<0.0001
𝐶^2	241.12	1	241.12	233.44	<0.0001
Residual	7.23	7	1.03
Lack of fit	4.60	3	1.53	2.34	0.2150
Pure error	2.63	4	0.66
Cor total	707.55	16
	𝑅^2=0.9898		𝑅^2Adj=0.9766