Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells
Figure 1
Cytotoxic effects of doxorubicin and decursin against multiple myeloma cells. (a) U266 cells were treated with various concentrations of decursin (0, 10, 20, 40, 80, or 160 M) for 24 h or 48 h. (b) U266 cells were treated with various concentrations of doxorubicin (0, 0.0625, 0.125, 0.25, 0.5, or 1 M) for 24 h or 48 h. (c) MM.1S cells were treated with various concentrations of decursin (0, 10, 20, 40, 80 or 160 M) for 24 or 48 h. (d) MM.1S cells were treated with various concentrations of doxorubicin (0, 0.0625, 0.125, 0.25, 0.5, or 1 M) for 24 or 48 h. (e) RPMI8226 cells were treated with various concentrations of decursin (0, 10, 20, 40, 80, or 160 M) for 24 or 48 h. (f) RPMI8226 cells were treated with various concentrations of doxorubicin (0, 0.0625, 0.125, 0.25, 0.5, or 1 M) for 24 or 48 h. Cytotoxicity of doxorubicin or decursin was evaluated by XTT assay. Data are presented as mean ± SD for triplicate experiments.
