A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling

Table 1

The grading system in quantifying blood stasis syndrome diagnosis standards.

Signs and symptom	Point
Purple tongue	(less severe) 8, (more severe) 10
Resistance to pressure in lower abdomen	(less severe) 8, (more severe) 10
Choppy pulse	10
Dark stool (Melena)	10
Pathogenic nodules	10
Distended veins under tongue	(less severe) 8, (more severe) 10
Irregular pulse	8
No pulse	10
Distended veins in abdominal wall	10
Hypodermal ecchymoses	(less severe) 8, (more severe) 10
Dark menstrual blood with clots	(less severe) 8, (more severe) 10
Persistent angina pectoris	10
General fixed pain	8
Dark red lips and gums	6
Small vessels	5
Numb extremities	5
Surgery history	5
Mucosal membrane of palate (+)	(less severe) 4, (more severe) 5
Paralysis in extremities	(less severe) 5, (more severe) 7
Psychiatric abnormality	(Irritability) 4, (Mania) 8
Rough skin	(less severe) 4, (more severe) 5
Complete blood viscosity (+)	10
Blood plasma viscosity (+)	5
External clot net weight (+)	10
External clot total weight (+)	8
Increase in platelet aggregation	10
Abnormality in blood clot elasticity	8
Microcirculation obstruction	10
Hemodynamics obstruction	10
Decrease in fiber dissolution activity	10
Resistance in platelet release	10
Pathogenic scan (+) for blood stasis	10
Blood vessel obstruction by new technology analysis	10

Grades <19 points are categorized as non-BSS. Grades 20–49 points are categorized as less severe BSS. Grades >50 points are categorized as more severe BSS [16, 22].