A Systems Biology Approach to Characterize Biomarkers for Blood Stasis Syndrome of Unstable Angina Patients by Integrating MicroRNA and Messenger RNA Expression Profiling

Table 5

Clinical characteristics of subjects of qRT-PCR.

	UA with BSS (𝑛=30)	UA with non-BSS (𝑛=30)	Controls (𝑛=15)	𝑃 value
Male gender (𝑛)	15 (50%)	15 (50%)	8 (53.3%)	0.974
Age (years)	57.06±5.62	57.67±6.43	56.87±6.70	0.896
BMI (kg/m^2)	24.58±1.52	24.10±2.13	23.63±1.52	0.231
Active smoker (𝑛)	17 (56.7%)	18 (60%)	6 (40%)	0.429
BSS Grades	73.93±2.91	14.03±2.22	0
Number of vessels (𝑛)	1.53±0.94	1.57±0.95	0
Hypertension (𝑛)	22 (73.3%)	23 (76.7%)	0	0.000
Type 2 diabetes mellitus (𝑛)	14 (46.7%)	15 (50%)	0	0.001
Total cholesterol (mmol/L)	4.19±0.83	4.19±0.95	3.71±0.76	0.172
LDL cholesterol (mmol/L)	2.60±0.59	2.55±0.58	2.37±0.54	0.436
HDL cholesterol (mmol/L)	1.13±0.21	1.12±0.21	1.31±0.29	0.032
Triglycerides (mmol/L)	1.79±0.89	1.89±1.04	1.03±0.27	0.001
CRP (mg/L)	3.93±2.21	3.98±2.26	2.73±2.05	0.122
Concurrent medication (𝑛)
Antiplatelet	100%	28 (93.3%)	0	0.000
Beta-blocker	20 (66.7%)	20 (66.7%)	0	0.000
ACEI/ARB	18 (60%)	16 (53.3%)	0	0.000
Calcium-channel blockers	13 (43.3%)	15 (50%)	0	0.001
Nitrates	22 (73.3%)	20 (66.7%)	0	0.000
Statin	26 (86.7%)	24 (80%)	0	0.000

Data represents means ± SEM. Abbreviations: ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker; BMI: body mass index; BSS: blood stasis syndrome; HDL: high-density protein; CRP: C-reactive protein; LDL: low-density protein.