Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

Figure 1

Effect of gastrodin on MPP⁺-induced neurotoxicity in the dopaminergic neuroblastoma SH-SY5Y cell line. Cells were exposed to gastrodin and 1 mM MPP⁺ for 48 h. Cell viability (A) and morphology of SH-SY5Y cells (B) after treatment with control (a), 1 mM MPP⁺ (b), 25 μM gastrodin (c), 25 μM gastrodin + 1 mM MPP⁺ (d), 5 μM gastrodin + 1 mM MPP⁺ (e), and 1 μM gastrodin + 1 mM MPP⁺ (f). Data are percentages of values in the untreated control cultures and are means ± standard errors of three independent experiments in triplicate. ^###𝑃<0.001 compared with the control group, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 compared with the MPP⁺-treated group (one-way analysis of variance followed by Tukey’s post hoc test).