Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

Figure 5

Gastrodin prevents poly(ADP-ribose) polymerase (PARP) cleavage against MPP⁺ in SH-SY5Y cells (a), the substantia nigra pars compacta (SNpC) (b), and striatum (c) after MPTP treatment. PARP protein levels were assessed by Western blot analysis in cells/animal tissues. Bar graphs show quantitative data for PARP signals that are normalized to the β-actin signal (𝑛=3-4 per group). Values are mean ± standard error (^###𝑃<0.01 versus vehicle group) and (^∗∗∗𝑃<0.001 and versus MPP⁺/MPTP group).

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