Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

Figure 6

Protective effect of gastrodin against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced behavioral dysfunction in a mouse model of Parkinson’s disease. Vehicle or different doses (10, 30, and 60 mg/kg) of gastrodin were administered orally once per day for 15 days, and MPTP (30 mg/kg, i.p.) was injected during the last 5 days. Seven days after the last MPTP injection, the time to arrive at the floor (total locomotor activity) (a) and the time to turn completely downward (T-turn) (b) were recorded with a cutoff limit of 60 s for the pole test. Motor deficit was indicated by the latency of fall (c) during the rotarod test. Values are mean ± standard error (^###𝑃<0.001 versus vehicle group) and (^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 versus MPTP group).

(a)

(b)

(c)