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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 516727, 10 pages
http://dx.doi.org/10.1155/2013/516727
Antioxidant Activity and Cardioprotective Effect of a Nonalcoholic Extract of Vaccinium meridionale Swartz during Ischemia-Reperfusion in Rats
1Laboratorio de Ciencia de Alimentos, Universidad Nacional de Colombia, Sede Medellín, Medellín, Colombia
2CONICET, Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina
3Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Burjassot, 46100 Valencia, Spain
4Cátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata and CIC Provincia de Buenos Aires, La Plata, Argentina
Received 30 May 2012; Revised 13 December 2012; Accepted 21 December 2012
Academic Editor: Adair Roberto Soares Santos
Copyright © 2013 Yasmin E. Lopera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- M. L. Weisfeldt, J. Zweier, G. Ambrosio, L. C. Becker, and J. T. Flaherty, “Evidence that free radicals result in reperfusion injury in heart muscle,” Basic Life Sciences, vol. 49, pp. 911–919, 1988. View at Scopus
- G. Ambrosio, J. L. Zweier, C. Duilio et al., “Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow,” The Journal of Biological Chemistry, vol. 268, no. 25, pp. 18532–18541, 1993. View at Scopus
- K. K. Griendling and G. A. FitzGerald, “Oxidative Stress and cardiovascular injury part I: Basic mechanisms and in vivo monitoring of ROS,” Circulation, vol. 108, no. 16, pp. 1912–1916, 2003. View at Publisher · View at Google Scholar · View at Scopus
- N. Marczin, N. El-Habashi, G. S. Hoare, R. E. Bundy, and M. Yacoub, “Antioxidants in myocardial ischemia-reperfusion injury: therapeutic potential and basic mechanisms,” Archives of Biochemistry and Biophysics, vol. 420, no. 2, pp. 222–236, 2003. View at Publisher · View at Google Scholar · View at Scopus
- O. I. Aruoma, T. Bahorun, and L. S. Jen, “Neuroprotection by bioactive components in medicinal and food plant extracts,” Mutation Research, vol. 544, no. 2-3, pp. 203–215, 2003. View at Publisher · View at Google Scholar · View at Scopus
- D. Bandyopadhyay, A. Chattopadhyay, G. Ghosh, and A. G. Datta, “Oxidative stress-induced ischemic heart disease: protection by antioxidants,” Current Medicinal Chemistry, vol. 11, no. 3, pp. 369–387, 2004. View at Publisher · View at Google Scholar · View at Scopus
- L. S. Cozma, “The role of anti-oxidant therapy in cardiovascular disease,” Current Opinion in Lipidology, vol. 15, no. 3, pp. 369–371, 2004. View at Publisher · View at Google Scholar
- C. A. Papaharalambus and K. K. Griendling, “Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury,” Trends in Cardiovascular Medicine, vol. 17, no. 2, pp. 48–54, 2007. View at Publisher · View at Google Scholar · View at Scopus
- B. Halliwell, “The wanderings of a free radical,” Free Radical Biology and Medicine, vol. 46, no. 5, pp. 531–542, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. M. Lefer and D. J. Lefer, “The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion,” Cardiovascular Research, vol. 32, no. 4, pp. 743–751, 1996. View at Publisher · View at Google Scholar · View at Scopus
- J. S. Kim, S. Ohshima, P. Pediaditakis, and J. J. Lemasters, “Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death after reperfusion,” Free Radical Biology and Medicine, vol. 37, no. 12, pp. 1943–1950, 2004. View at Publisher · View at Google Scholar · View at Scopus
- G. Schinella, J. C. Fantinelli, and S. M. Mosca, “Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism,” Clinical Nutrition, vol. 24, no. 3, pp. 360–366, 2005. View at Publisher · View at Google Scholar · View at Scopus
- L. M. Hung, M. J. Su, and J. K. Chen, “Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms,” Free Radical in Biololgy and Medicine, vol. 36, no. 6, pp. 774–781, 2004. View at Publisher · View at Google Scholar
- B. Haliwell, “Are polyphenols anti-oxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?” Archives of Biochemistry and Biophysics, vol. 476, no. 2, pp. 107–112, 2008. View at Publisher · View at Google Scholar
- S. M. Mosca, G. R. Schinella, H. A. Tournier, and H. E. Cingolani, “Is the protection against ischemia induced by red wine linked to its antioxidant capacity?” Experimental and Clinical Cardiology, vol. 6, no. 4, pp. 183–187, 2001. View at Scopus
- J. C. Fantinelli, G. Schinella, H. E. Cingolani, and S. M. Mosca, “Effects of different fractions of a red wine non-alcoholic extract on ischemia-reperfusion injury,” Life Sciences, vol. 76, no. 23, pp. 2721–2733, 2005. View at Publisher · View at Google Scholar · View at Scopus
- G. Schinella, J. C. Fantinelli, H. Tournier et al., “Antioxidant and cardioprotective effects of Ilex brasiliensis: a comparative study with Ilex paraguariensis (yerba mate),” Food Research International, vol. 42, no. 10, pp. 1403–1409, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Yanagi, K. Matsumura, A. Marui et al., “Oral pretreatment with a green tea polyphenol for cardioprotection against ischemia-reperfusion injury in an isolated rat heart model,” Journal of Thoracic and Cardiovascular Surgery, vol. 141, no. 2, pp. 511–517, 2011. View at Publisher · View at Google Scholar · View at Scopus
- L. Djoussé, P. N. Hopkins, K. E. North, J. S. Pankow, D. K. Arnett, and R. C. Ellison, “Chocolate consumption is inversely associated with prevalent coronary heart disease: the national heart, lung, and blood institute family heart study,” Clinical Nutrition, vol. 30, no. 2, pp. 182–187, 2011. View at Publisher · View at Google Scholar · View at Scopus
- H. G. Ávila, J. A. Cuspoca, G. Fischer, G. A. Ligarreto, and M. C. Quicazán, “Caracterización fisicoquímica y organoléptica del fruto de agraz (Vaccinium meridionale Swartz) almacenado a 2 °C,” Revista Facultad Nacional de Agronomía, Medellín, vol. 60, no. 2, pp. 4179–4193, 2007.
- G. A. Ligarreto, M. del Patiño, and S. V. Magnitskiy, “Phenotypic plasticity of Vaccinium meridionale (Ericaceae) in wild populations of mountain forests in Colombia,” Revista de Biologia Tropical, vol. 59, no. 2, pp. 569–583, 2011. View at Scopus
- R. L. Prior, G. Cao, R. L. Prior, and G. Cao, “Analysis of botanicals and dietary supplements for antioxidant capacity: a review,” Journal of AOAC International, vol. 83, no. 4, pp. 950–956, 2000. View at Scopus
- G. A. Garzón, C. E. Narváez, K. M. Riedl, and S. J. Schwartz, “Chemical composition, anthocyanins, non-anthocyanin phenolics and antioxidant activity of wild bilberry (Vaccinium meridionale Swartz) from Colombia,” Food Chemistry, vol. 122, no. 4, pp. 980–986, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Rommel, R. E. Wrolstad, and D. A. Heatherbell, “Blackberry juice and wine: processing and storage effects on anthocyanin composition, color and appearance,” Journal of Food Science, vol. 57, no. 2, pp. 385–391, 1992. View at Publisher · View at Google Scholar
- N. P. Seeram, Y. Zhang, and M. G. Nair, “Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins,” Nutrition and Cancer, vol. 46, no. 1, pp. 101–106, 2003. View at Scopus
- N. P. Seeram, “Recent trends and advances in berry health benefits research,” Journal of Agricultural and Food Chemistry, vol. 58, no. 7, pp. 3869–3870, 2010. View at Publisher · View at Google Scholar · View at Scopus
- I. Ahmet, E. Spangler, B. Shukitt-Hale, J. A. Joseph, D. K. Ingram, and M. Talan, “Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats,” PLoS ONE, vol. 4, no. 11, Article ID e7975, 2009. View at Publisher · View at Google Scholar · View at Scopus
- V. I. Singleton and J. A. Rossi Jr., “Colorimetry of total phenolics with phosphomolybdic acid reagents,” American Journal of Enology and Viticulture, vol. 16, no. 3, pp. 144–158, 1965.
- C. Chiriboga and F. J. Francis, “An anthocyanin recovery system from cranberry pomace,” Proceeding of the American Society of Horticultural Sciences, vol. 95, no. 2, pp. 233–236, 1970.
- A. Cavin, K. Hostettmann, W. Dyatmyko, and O. Potterat, “Antioxidant and lipophilic constituents of Tinospora crispa,” Planta Medica, vol. 64, no. 5, pp. 393–396, 1998. View at Publisher · View at Google Scholar · View at Scopus
- R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, and C. Rice-Evans, “Antioxidant activity applying an improved ABTS radical cation decolorization assay,” Free Radical Biology and Medicine, vol. 26, no. 9-10, pp. 1231–1237, 1999. View at Publisher · View at Google Scholar · View at Scopus
- I. F. F. Benzie and J. J. Strain, “The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay,” Analytical Biochemistry, vol. 239, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar · View at Scopus
- W. H. Koppenol, R. Kissner, and J. S. Beckman, “Syntheses of peroxynitrite: to go with the flow or on solid grounds?” Methods in Enzymology, vol. 269, pp. 296–302, 1996. View at Scopus
- G. G. A. Balavoine and Y. V. Geletii, “Peroxynitrite scavenging by different antioxidants—part I: convenient assay,” Nitric Oxide, vol. 3, no. 1, pp. 40–54, 1999. View at Publisher · View at Google Scholar · View at Scopus
- K. Jiao, S. Mandapati, P. L. Skipper, S. R. Tannenbaum, and J. S. Wishnok, “Site-selective nitration of tyrosine in human serum albumin by peroxynitrite,” Analytical Biochemistry, vol. 293, no. 1, pp. 43–52, 2001. View at Publisher · View at Google Scholar · View at Scopus
- J. A. Buege and S. D. Aust, “Microsomal lipid peroxidation,” Method in Enzymology, vol. 52, pp. 302–309, 1978. View at Publisher · View at Google Scholar
- J. Sedlak and R. H. Lindsay, “Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent,” Analytical Biochemistry, vol. 25, no. 1, pp. 192–205, 1968. View at Scopus
- J. M. Hare, “Nitroso-redox balance in the cardiovascular system,” The New England Journal of Medicine, vol. 351, no. 20, pp. 2112–2114, 2004. View at Publisher · View at Google Scholar
- N. Paolocc, U. E. G. Ekelund, T. Isoda et al., “cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation,” American Journal of Physiology, vol. 279, no. 4, pp. H1982–H1988, 2000. View at Scopus
- F. J. Giordano, “Oxygen, oxidative stress, hypoxia, and heart failure,” Journal of Clinical Investigation, vol. 115, no. 3, pp. 500–508, 2005.
- P. Wang and J. L. Zweier, “Measurement of nitric oxide and peroxynitrite generation in the postischemic heart: evidence for peroxynitrite-mediated reperfusion injury,” The Journal of Biological Chemistry, vol. 271, no. 46, pp. 29223–29230, 1996. View at Publisher · View at Google Scholar · View at Scopus
- T. Katori, S. Donzelli, C. G. Tocchetti et al., “Peroxynitrite and myocardial contractility: in vivo versus in vitro effects,” Free Radical Biology and Medicine, vol. 41, no. 10, pp. 1606–1618, 2006. View at Publisher · View at Google Scholar
- R. Bolli, “Causative role of oxyradicals in myocardial stunning: a proven hypothesis. A brief review of the evidence demonstrating a major role of reactive oxygen species in several forms of postischemic dysfunction,” Basic Research in Cardiology, vol. 93, no. 3, pp. 156–162, 1998. View at Publisher · View at Google Scholar · View at Scopus
- B. Tavazzi, D. Di Pierro, M. Bartolini et al., “Lipid peroxidation, tissue necrosis, and metabolic and mechanical recovery of isolated reperfused rat heart as a function of increasing ischemia,” Free Radical Research, vol. 28, no. 1, pp. 25–37, 1998. View at Scopus
- B. J. Michell, J. E. Griffiths, K. I. Mitchelhill et al., “The Akt kinase signals directly to endothelial nitric oxide synthase,” Current Biology, vol. 9, no. 15, pp. 845–848, 1999. View at Publisher · View at Google Scholar · View at Scopus
- O. D. Saugstad, “Does nitric oxide prevent oxidative mediated lung injury?” Acta Paediatrica, vol. 89, no. 8, pp. 905–907, 2000. View at Publisher · View at Google Scholar
- R. M. Clancy, D. Levartovsky, J. Leszczynska-Piziak, J. Yegudin, and S. B. Abramson, “Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary,” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 9, pp. 3680–3684, 1994. View at Scopus
- P. C. Wootton-Beard and L. Ryan, “Improving public health? The role of anti-oxidant-rich fruit and vegetable beverages,” Food Research International, vol. 44, no. 10, pp. 3135–3148, 2011. View at Publisher · View at Google Scholar