The effect of PN-1, a Traditional Chinese Prescription, on the Learning and Memory in a Transgenic Mouse Model of Alzheimer’s Disease

Figure 5

Effects of PN-1 treatment (mg/kg once a day) on the expressions of plasticity-related proteins. The top panels show a representative western blots, and the bottom panels show the quantitation of changes in protein levels by densitometry. (a) The levels of Syt 1, CaM, and BDNF expressions. (b) The phosphorylation status of CaMKII𝛼  and CREB. Data represent means ± SEM (𝑛=6 mice/group) from 3 independent experiments. *𝑃<0.05, **𝑃<0.01  versus the vehicle-treated group. ^#𝑃<0.05, ^##𝑃<0.01  versus the wild-type group.

(a)  

(b)