Curcumin Protects against 1-Methyl-4-phenylpyridinium Ion- and Lipopolysaccharide-Induced Cytotoxicities in the Mouse Mesencephalic Astrocyte via Inhibiting the Cytochrome P450 2E1

Figure 6

The schematic mechanism of Cur in protecting against MPP⁺- and LPS-induced cytotoxicities in the primary mesencephalic astrocytes. CYP2E1 is a main enzyme catalyzing the small polar molecules into oxgen ions, peroxides, and other cytotoxic agents such as isoquinoline derivatives. MPP⁺ and LPS activated the CYP2E1 and induced mesencephalic astrocyte damage. Cur inhibited the CYP2E1 expression and activity, reduced the ROS production, and protected against MPP⁺- and LPS-induced cytotoxicities in the mesencephalic astrocytes.