Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats: Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis
Figure 5
Hepatic expression of mRNAs encoding sterol regulatory element-binding protein- (SREBP-) 1c (a), fatty acid synthase (FAS) (c), acetyl-CoA carboxylase- (ACC-) 1 (d) and stearoyl-CoA desaturase- (SCD-) 1 (e), and nuclear SREBP-1 protein (b) in water-control, 10% fructose solution-control, and fructose pair-fed oleanolic acid- (OA-) treated rats at week 10. Animals were administered with OA (25 mg/kg/day) or vehicle (OA: 0 mg/kg, 5% Gum Arabic) by oral gavage daily for 10 weeks. mRNA was determined by real-time PCR. Protein expression was determined by Western blot. Data are means ± SEM ( each group). .
