Oleanolic Acid Diminishes Liquid Fructose-Induced Fatty Liver in Rats: Role of Modulation of Hepatic Sterol Regulatory Element-Binding Protein-1c-Mediated Expression of Genes Responsible for De Novo Fatty Acid Synthesis
Figure 7
Hepatic expression of mRNAs encoding peroxisome proliferator-activated receptor-(PPAR-) γ (a), PPAR-α (b), carnitine palmitoyltransferase- (CPT-) 1a (c), acyl-CoA oxidase (ACO) (d), CD36 (e), and glucose-6-phosphatase (G6Pase) (f) in water-control, 10% fructose solution-control and fructose pair-fed oleanolic acid- (OA-)treated rats at week 10. Animals were administered with OA (25 mg/kg/day) or vehicle (OA: 0 mg/kg, 5% Gum Arabic) by oral gavage daily for 10 weeks. mRNA was determined by real-time PCR. Data are means ± SEM ( each group). .
