Multicomponent Therapeutics of Berberine Alkaloids

Table 1

Quadratic rotation-orthogonal combination design and results.

No.	JAT	COP	BER	EPI	PAL	Inhibiting ratio (%)
1	1	1	1	1	1	90.6
2	1	1	1	−1	−1	70.0
3	1	1	−1	1	−1	50.7
4	1	1	−1	−1	1	44.1
5	1	−1	1	1	−1	66.3
6	1	−1	1	−1	1	72.9
7	1	−1	−1	1	1	30.0
8	1	−1	−1	−1	−1	32.5
9	−1	1	1	1	−1	43.0
10	−1	1	1	−1	1	70.4
11	−1	1	−1	1	1	52.3
12	−1	1	−1	−1	−1	30.4
13	−1	−1	1	1	1	61.9
14	−1	−1	1	−1	−1	26.3
15	−1	−1	−1	1	−1	37.3
16	−1	−1	−1	−1	1	16.2
17	−2	0	0	0	0	20.9
18	2	0	0	0	0	40.4
19	0	−2	0	0	0	29.3
20	0	2	0	0	0	71.0
21	0	0	−2	0	0	23.9
22	0	0	2	0	0	40.4
23	0	0	0	−2	0	17.8
24	0	0	0	2	0	39.2
25	0	0	0	0	−2	9.5
26	0	0	0	0	2	30.8
27	0	0	0	0	0	23.8
28	0	0	0	0	0	41.8
29	0	0	0	0	0	42.8
30	0	0	0	0	0	28.6
31	0	0	0	0	0	39.5
32	0	0	0	0	0	44.9
33	0	0	0	0	0	39.0
34	0	0	0	0	0	30.3
35	0	0	0	0	0	41.5
36	0	0	0	0	0	36.7