Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats

<table>Effect of KIOM-79 treatment on RAGE expression in the heart. RAGE mRNA expression (a) and RAGE protein expression (b) in Zucker lean rat (ZL), Zucker diabetic rat (ZDF), ZDF rat treated with KIOM-79 at 50 mg/kg (KIOM-79-50), and ZDF rat treated with KIOM-79 at 500 mg/kg (KIOM-79-500). All data were expressed as the mean ± S.E.M. *<svg height="11.375" id="M30" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to ZL rats; <sup>#</sup><svg height="11.375" id="M31" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared to untreated ZDF rats.</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Effect of KIOM-79 on Diabetes-Induced Myocardial Fibrosis in Zucker Diabetic Fatty Rats 