548498.fig.004a
(a)
548498.fig.004b
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548498.fig.004c
(c)
Figure 4: (a) The protein-protein interaction (PPI) network of known targets of rheumatoid arthritis (RA) and candidate effector molecules of Wu Tou Tang based on their PPI data. In total, there are 6713 interactions between 3231 proteins in the PPI network. (b) The PPI network of 129 hub proteins obtained from (a). Yellow nodes refer to known targets of RA, and green nodes refer to candidate effector molecules of Wu Tou Tang. Pathway with blue edges refer to neuroactive ligand-receptor interaction, which is the most associated pathway of candidate effector molecules of Wu Tou Tang according to the pathway enrichment analysis. (c) The interaction network of five ingredients in Wu Tou Tang and nine major candidate effector molecules of Wu Tou Tang on RA therapy. Square nodes refer to ingredients in Wu Tou Tang, and circular nodes refer to major candidate effector molecules of Wu Tou Tang on RA therapy.