Anacardic Acids from Cashew Nuts Ameliorate Lung Damage Induced by Exposure to Diesel Exhaust Particles in Mice

Table 1

Effects of supplementation with anacardic acids on the cellular profile of the bronchoalveolar lavage fluid in mice instilled with diesel exhaust particles.

Differential cells (×10^4)	Ctrl	DEP	DA50	DA150	DA250
Total Cells	5.88±2.61	6.76±2.05	8.10±1.61	8.74±1.42	7.52±0.99
Eosinophils	0.00 (0.00)	0.00 (0.06)	0.00 (0.02)	0.00 (0.19)	0.00 (0.00)
Neutrophils	0.04 (0.24)	0.12 (0.13)	0.21 (0.36)	0.20 (0.31)	0.23 (0.10)^a
Lymphocytes	0.63±0.42	0.47±0.71	0.99±0.56	1.33±0.64^a	1.17±0.80
Macrophages	4.38±2.24	5.36±1.77	5.86±1.06	6.33±1.32	5.37±0.73
Caliciform cells	0.41±0.26	0.47±0.41	0.57±0.36	0.19±0.19	0.24±0.19
Ciliary cells	0.31±0.27	0.26±0.17	0.41±0.20	0.54±0.47	0.44±0.27

Values are expressed as the means ± SD or as medians (interquartile range). aP < 0.05 significant difference compared to DEP. AAs: anacardic acids. Ctrl: control, animals received an intranasal instillation of 10 𝜇L saline solution and were treated orally with 100 μL of cashew nut oil (CNO). DEP: diesel exhaust particles, intranasal instillation of 50 𝜇g DEP/10 𝜇L of saline and treated orally with 100 μL of CNO. DA50: intranasal instillation of 50 𝜇g DEP/10 𝜇L of saline and treated orally with 50 mg/kg of AAs. DA150: intranasal instillation of 50 𝜇g DEP/10 𝜇L of saline and treated orally with 150 mg/kg of AAs. DA250: intranasal instillation of 50 𝜇g DEP/10 𝜇L of saline and treated orally with 250 mg/kg of AAs.