Anacardic Acids from Cashew Nuts Ameliorate Lung Damage Induced by Exposure to Diesel Exhaust Particles in Mice

Table 2

Effects of supplementation with anacardic acids on cytokine concentration in the bronchoalveolar lavage fluid in mice instilled with diesel exhaust particles.

Cytokines	Ctrl	DEP	DA50	DA150	DA250
IL-1β (ρg/mL)	189.40±43.56	228.52±66.25	181.51±66.30	451.45±138.14^b	459.72±175.81^b
TNF-α (ρg/mL)	19.84±10.87	118.86±54.24^a	25.83±6.42^b	112.44±37.73	130.83±64.67
IL-6 (ρg/mL)	61.96±40.73	74.84±42.84	62.58±46.53	118.11±77.08	103.04±51.44
IL-10 (ρg/mL)	1126.36±463.89	1526.35±538.16	1362.49±217.83	1862.99±646.02	1508.36±499.59

Values are expressed as the means ± SD. aP < 0.001 statistical difference compared to Ctrl. bP < 0.05 significant difference compared to DEP. AAs: anacardic acids. Ctrl: control, animals received an intranasal instillation of 10 𝜇L saline solution and were treated orally with 100 μL of cashew nut oil (CNO). DEP: diesel exhaust particles, intranasal instillation of 50 𝜇g DEP/10 𝜇L of saline and treated orally with 100 μL of CNO. DA50: intranasal instillation of 50 μg DEP/10 𝜇L of saline and treated orally with 50 mg/kg of AAs. DA150: intranasal instillation of 50 𝜇g DEP/10 𝜇L of saline and treated orally with 150 mg/kg of AAs. DA250: intranasal instillation of 50 μg DEP/10 𝜇L of saline and treated orally with 250 mg/kg of AAs.