Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication

Figure 6

Synergistic effect of PGSM on IFN-α-induced anti-HCV activity in HCV replicon cells. HCV subgenomic replicon cells (genotype 1b) were treated with the indicated amounts of either PGSM or IFN-α alone or both as indicated. Culture media containing fresh compounds were replaced every three days. At the indicated time points after treatments, intracellular HCV RNA levels were determined by qRT-PCR. The copy number of HCV RNA was calculated from cells treated with compound as compared to that for control. Control indicates that cells were treated with 0.2% DMSO (vehicle).