Triterpenoid Saponins Isolated from Platycodon grandiflorum Inhibit Hepatitis C Virus Replication

Table 1

Specification of chemical structure and anti-HCV activities of triterpenoid saponin extracts of Platycodon grandiflorum on NS5B RdRp and NS3/4A protease functions.

Compounds	Aglycone	Composition of sugar		HCV enzyme (IC50, 𝜇g/mL)
		C-3	C-28	HCV; NS5B	HCV; NS3/4A
PG-extract	—	—	—	67	>100
PGSM	—	—	—	5	>100
Platycodin D	Platycodigenin	Glc-	Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara-	5	>100
Platycodin D2		Glc-(1→3)-Glc-	Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara-	6	>100
Platycodin D3		Glc-(1→6)-Glc-	Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara-	8	>100
Deapioplatycodin D		Glc-	Xyl-(1→4)-Rha-(1→2)-Ara-	7	>100
Deapioplatycodin D2		Glc-(1→3)-Glc-	Xyl-(1→4)-Rha-(1→2)-Ara-	10	>100
Platyconic acid A	Platycogenic acid A	Glc-	Api-(1→3)-Xyl-(1→4)-Rha-(1→2)-Ara-	15	>100