Attenuation of CCl₄-Induced Oxidative Stress and Hepatonephrotoxicity by Saudi Sidr Honey in Rats

Table 3

Effect of honey on CCl₄-induced kidney function test in serum.

Treatment group (𝑛=6)	Creatinine; (mg/dL)	Uric Acid; (mg/dL)	Urea; (mmol/L)	Sodium; (mEq/L)	Potassium; (mEq/L)	Calcium; (mg/dL)
Normal control	1.34±0.09	1.28±0.010	35.8±1.90	54.96±0.99	3.61±0.18	4.42±0.34
CCl4 only (1.25 mL/kg)	7.48±0.31^***a	5.68±0.36^***a	167.16±4.65^***a	101.89±2.26^***a	10.58±0.48^***a	24.64±0.81^***a
Honey (0.5 g/kg) + CCl4	6.48±0.31^*b	4.25±0.43^*b	157.5±5.51^b	88.67±2.35^**b	9.18±0.27^*b	20.42±0.98^**b
Honey (1.0 g/kg) + CCl4	5.11±0.13^***b	2.89±0.21^***b	131.83±8.15^**b	78.14±2.30^***b	7.31±0.23^***b	13.76±0.87 ***
Silymarin (10 mg/kg) + CCl4	6.08±0.27^**b	4.30±0.25^*b	154.66±5.85^b	93.44±3.20^*b	10.05±0.40^b	25.12±0.84^b

All values represent mean ± SEM. *𝑃<0.05; **𝑃<0.01; ***𝑃<0.001; ANOVA, followed by Dunnett’s multiple comparison test.
^aAs compared with normal group, ^bAs compared with CCl₄ only group.