Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
Figure 1
Inhibitory effects of ellagic acid on platelet aggregation in washed human platelets. (a) Chemical structure of ellagic acid. (b)–(d) Washed platelets ( cells/mL) were preincubated with 20–120 μM ellagic acid or 0.5% DMSO; this was followed by the addition of 1 μg/mL collagen (○), 1 M U46619 (▽), 60 M arachidonic acid (□), or 0.05 IU/mL thrombin (⋄) to trigger platelet aggregation and an ATP-release reaction ((c), upper tracings). The data in (b) are presented as the means ± S.E.M. (). The profiles ((c) and (d)) are representative examples of 4 similar experiments.
