Antidiabetic and Hypolipidemic Activities of Curculigo latifolia Fruit:Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats

Table 7

Expression of candidate genes in muscle tissue.

Group	IRS1	IGF	GLUT4	PPARγ	PPARα	AdipoR1	AdipoR2	Leptin	LPL	Lipase	Gapdh
Group 1	1.8260	1.9954	0.9704	1.5499	1.3345	1.4130	1.2861	1.3915	0.5263	0.5804	0.7407
Group 2	0.8634	0.9465	0.5567	0.4557	0.7075	0.5208	0.4300	2.5701*	0.9524	0.9544	0.9787
Group 3	0.5530	0.6140*	0.5163	0.3232	0.5192	0.4040	0.3334	0.6173*	0.7185	0.7652	1.0191
Group 4	1.3284*	5.2166*	1.3854*	2.0186*	3.0955*	1.4058*	1.5691*	2.1324*	0.8530	1.9529*	1.1178
Group 5	1.4668*	5.3301*	1.9030*	2.4303*	3.2608*	1.4815*	1.5556*	2.2548*	0.7183	1.6386*	1.2593*
Group 6	1.7949*	5.6444*	2.8137*	3.5724*	3.8732*	2.5713*	2.8885*	3.2222*	0.5769	2.0382*	1.3244*
Group 7	1.2346*	4.0180*	1.0819*	0.3098	0.2155	0.8305	1.3058*	0.3030	1.1089*	0.9428	1.2346*

Data are means ± SD for expression of candidate genes in muscle tissue of normal rats (Group 1), obese rats (Group 2), diabetic control rats (Group 3), diabetic rats treated with 50 mg/kg bw of C. latifolia fruit:root extracts (Group 4), diabetic rats treated with 100 mg/kg bw of C. latifolia fruit:root extracts (Group 5), diabetic rats treated with 200 mg/kg bw of C. latifolia fruit:root extracts (Group 6), and diabetic rats treated with 10 mg/kg bw of glibenclamide (Group 7).
Significant difference is at *𝑃<0.05 when compared with diabetic control rats (Group 3).