Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11)

Figure 5

Inhibitory effects of the nine test compounds on hOAT4-mediated ES uptake. Ten minute uptake of [³H]ES (1 μM) was measured in CHO-hOAT4 cells in the absence and presence of test compounds (50 μM) or ES (1000 μM for self-inhibition). Data represent hOAT4-mediated transport specifically, that is, data have been corrected for background ES accumulation measured in empty vector transfected cells. Values are mean±S.D. of triplicate values from a representative experiment. ^∗denotes𝑃<0.05, and ^∗∗∗denotes𝑃<0.001 as determined by one-way ANOVA followed by Dunnett’s t-test.