Therapeutic Effects of Water Soluble Danshen Extracts on Atherosclerosis
Figure 4
Blood thinning effect of Danshen extract. (a)–(c) Danshen extract (DE) pretreated at a dose of 10 mg/kg daily for 2 weeks via oral sonde ( in each group). (a) Bleeding time in response to treatment with DE. (b) Gross changes in the tail vein 96 h after κ-carrageenan injection. The white bar indicates the position 13 cm from the tail tip. The black bar indicates the reference length. (c) The length of thrombosis after κ-carrageenan injection. In the tail vein thrombosis rat model, DE treatment significantly inhibited thrombosis formation at 96 h after κ-carrageenan injection. (d) Platelet aggregation after DE treatment in ex vivo condition. The impedance aggregometer revealed that DE prevented platelet aggregation in a dose-dependent manner ex vivo. (e) Platelet aggregation after DE treatment in in vivo condition. Whole blood was sampled after DE pretreatment. Danshen extract (DE) administered at a dose of 10 mg/kg/d (DE 10) or 50 mg/kg/d (DE 50) for 2 weeks via oral sonde ( in each group). The platelet aggregation that was induced by ADP recovered more quickly with increasing doses of DE used in pretreatment. Graph of impedance aggregometer represented the mean value of each group. Results are expressed as the mean ± standard error. * versus vehicle treatment. DE: Danshen extract.
