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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 629750, 12 pages
http://dx.doi.org/10.1155/2013/629750
Research Article

Involvement of Endoplasmic Reticulum Stress in Capsaicin-Induced Apoptosis of Human Pancreatic Cancer Cells

1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China
2Department of Hepatobiliary-Pancreatic Surgery, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, China

Received 29 September 2012; Revised 31 March 2013; Accepted 23 April 2013

Academic Editor: Taiping Fan

Copyright © 2013 Shengzhang Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Raimondi, P. Maisonneuve, and A. B. Lowenfels, “Epidemiology of pancreatic cancer: an overview,” Nature Reviews Gastroenterology and Hepatology, vol. 6, no. 12, pp. 699–708, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Vincent, J. Herman, R. Schulick, R. H. Hruban, and M. Goggins, “Pancreatic cancer,” The Lancet, vol. 378, no. 9791, pp. 607–720, 2011. View at Publisher · View at Google Scholar
  3. A. Stathis and M. J. Moore, “Advanced pancreatic carcinoma: current treatment and future challenges,” Nature Reviews Clinical Oncology, vol. 7, no. 3, pp. 163–172, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Andersson, U. Aho, B. I. Nilsson et al., “Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions,” Scandinavian Journal of Gastroenterology, vol. 44, no. 7, pp. 782–786, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Hartel, F. F. Di Mola, F. Selvaggi et al., “Vanilloids in pancreatic cancer: potential for chemotherapy and pain management,” Gut, vol. 55, no. 4, pp. 519–528, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. R. Zhang, I. Humphreys, R. P. Sahu, Y. Shi, and S. K. Srivastava, “In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway,” Apoptosis, vol. 13, no. 12, pp. 1465–1478, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. W. T. Wei, H. Chen, Z. L. Ni et al., “Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation,” International Journal of Oncology, vol. 39, no. 6, pp. 1381–1390, 2011.
  8. W. T. Wei, H. Chen, Z. H. Wang et al., “Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway,” International Journal of Biological Sciences, vol. 8, no. 1, pp. 1–14, 2012.
  9. G. A. Cordell and O. E. Araujo, “Capsaicin: identification, nomenclature, and pharmacotherapy,” The Annals of Pharmacotherapy, vol. 27, no. 3, pp. 330–336, 1993. View at Scopus
  10. D. G. Barceloux, “Pepper and capsaicin (Capsicum and Piper species),” Disease-a-Month, vol. 55, no. 6, pp. 380–390, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. J. Caterina, M. A. Schumacher, M. Tominaga, T. A. Rosen, J. D. Levine, and D. Julius, “The capsaicin receptor: a heat-activated ion channel in the pain pathway,” Nature, vol. 389, no. 6653, pp. 816–824, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. J. Surh, “More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide,” Journal of the National Cancer Institute, vol. 94, no. 17, pp. 1263–1265, 2002. View at Scopus
  13. A. M. Sanchez, M. G. Sanchez, S. Malagarie-Cazenave, N. Olea, and I. Diaz-Laviada, “Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin,” Apoptosis, vol. 11, no. 1, pp. 89–99, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Y. Kim, E. H. Kim, S. U. Kim, T. K. Kwon, and K. S. Choi, “Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation,” Carcinogenesis, vol. 31, no. 3, pp. 367–375, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Ito, T. Nakazato, K. Yamato et al., “Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species,” Cancer Research, vol. 64, no. 3, pp. 1071–1078, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. H. Wang, H. Chen, H. C. Guo et al., “Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo,” International Journal of Oncology, vol. 39, no. 5, pp. 1123–1131, 2011.
  17. V. I. Rasheva and P. M. Domingos, “Cellular responses to endoplasmic reticulum stress and apoptosis,” Apoptosis, vol. 14, no. 8, pp. 996–1007, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Walter and D. Ron, “The unfolded protein response: from stress pathway to homeostatic regulation,” Science, vol. 334, no. 6059, pp. 1081–1086, 2011. View at Publisher · View at Google Scholar
  19. S. Oyadomari and M. Mori, “Roles of CHOP/GADD153 in endoplasmic reticulum stress,” Cell Death and Differentiation, vol. 11, no. 4, pp. 381–389, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. L. G. Haas, “BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum,” Experientia, vol. 50, no. 11-12, pp. 1012–1020, 1994. View at Publisher · View at Google Scholar · View at Scopus
  21. R. V. Rao, A. Peel, A. Logvinova et al., “Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78,” The FEBS Letters, vol. 514, no. 2-3, pp. 122–128, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. R. J. Kaufman, “Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls,” Genes & Development, vol. 13, no. 30, pp. 1211–1233, 1999. View at Publisher · View at Google Scholar
  23. Q. J. Quinones, G. G. de Ridder, and S. V. Pizzo, “GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum,” Histology and Histopathology, vol. 23, no. 11, pp. 1409–1416, 2008. View at Scopus
  24. S. H. Oh and S. C. Lim, “Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 329, no. 1, pp. 112–122, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. S. W. Ip, S. H. Lan, H. F. Lu et al., “Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress,” Human and Experimental Toxicology, vol. 31, no. 6, pp. 539–549, 2012. View at Publisher · View at Google Scholar
  26. R. K. Reddy, C. Mao, P. Baumeister, R. C. Austin, R. J. Kaufman, and A. S. Lee, “Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors. Role of ATP binding site in suppression of caspase-7 activation,” Journal of Biological Chemistry, vol. 278, no. 23, pp. 20915–20924, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. L. H. Zhang and X. Zhang, “Roles of GRP78 in physiology and cancer,” Journal of Cellular Biochemistry, vol. 110, no. 6, pp. 1299–1305, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Lee, A. J. Bruce-Keller, Y. Kruman, S. L. Chan, and M. P. Mattson, “2-deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins,” Journal of Neuroscience Research, vol. 57, no. 1, pp. 48–61, 1999. View at Publisher · View at Google Scholar
  29. R. V. Rao, H. M. Ellerby, and D. E. Bredesen, “Coupling endoplasmic reticulum stress to the cell death program,” Cell Death and Differentiation, vol. 11, no. 4, pp. 372–380, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. I. Tabas and D. Ron, “Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress,” Nature Cell Biology, vol. 13, no. 3, pp. 184–190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Zinszner, M. Kuroda, X. Wang et al., “CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum,” Genes & Development, vol. 12, no. 7, pp. 982–995, 1998. View at Scopus
  32. D. Ron and J. F. Habener, “CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription,” Genes & Development, vol. 6, no. 3, pp. 439–453, 1992. View at Scopus
  33. M. V. Barone, A. Crozat, A. Tabaee, L. Philipson, and D. Ron, “CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest,” Genes & Development, vol. 8, no. 4, pp. 453–464, 1994. View at Scopus
  34. E. Topkan, C. Parlak, A. Kotek, A. F. Yapar, and B. Pehlivan, “Predictive value of metabolic 18FDG-PET response on outcomes in patients with locally advanced pancreatic carcinoma treated with definitive concurrent chemoradiotherapy,” BMC Gastroenterology, vol. 11, article 23, 2011.
  35. A. F. Shields, “PET imaging of tumor growth: not as easy as it looks,” Clinical Cancer Research, vol. 18, no. 5, pp. 1189–1191, 2012. View at Publisher · View at Google Scholar
  36. C. Zhao, Z. Chen, X. Ye et al., “Imaging a pancreatic carcinoma xenograft model with 11C-acetate: a comparison study with 18F-FDG,” Nuclear Medicine Communications, vol. 30, no. 12, pp. 971–977, 2009. View at Publisher · View at Google Scholar · View at Scopus