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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 629750, 12 pages
Involvement of Endoplasmic Reticulum Stress in Capsaicin-Induced Apoptosis of Human Pancreatic Cancer Cells
1Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine,
Hangzhou, Zhejiang 310003, China
2Department of Hepatobiliary-Pancreatic Surgery, The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, China
Received 29 September 2012; Revised 31 March 2013; Accepted 23 April 2013
Academic Editor: Taiping Fan
Copyright © 2013 Shengzhang Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. Raimondi, P. Maisonneuve, and A. B. Lowenfels, “Epidemiology of pancreatic cancer: an overview,” Nature Reviews Gastroenterology and Hepatology, vol. 6, no. 12, pp. 699–708, 2009.
- A. Vincent, J. Herman, R. Schulick, R. H. Hruban, and M. Goggins, “Pancreatic cancer,” The Lancet, vol. 378, no. 9791, pp. 607–720, 2011.
- A. Stathis and M. J. Moore, “Advanced pancreatic carcinoma: current treatment and future challenges,” Nature Reviews Clinical Oncology, vol. 7, no. 3, pp. 163–172, 2010.
- R. Andersson, U. Aho, B. I. Nilsson et al., “Gemcitabine chemoresistance in pancreatic cancer: molecular mechanisms and potential solutions,” Scandinavian Journal of Gastroenterology, vol. 44, no. 7, pp. 782–786, 2009.
- M. Hartel, F. F. Di Mola, F. Selvaggi et al., “Vanilloids in pancreatic cancer: potential for chemotherapy and pain management,” Gut, vol. 55, no. 4, pp. 519–528, 2006.
- R. Zhang, I. Humphreys, R. P. Sahu, Y. Shi, and S. K. Srivastava, “In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway,” Apoptosis, vol. 13, no. 12, pp. 1465–1478, 2008.
- W. T. Wei, H. Chen, Z. L. Ni et al., “Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation,” International Journal of Oncology, vol. 39, no. 6, pp. 1381–1390, 2011.
- W. T. Wei, H. Chen, Z. H. Wang et al., “Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway,” International Journal of Biological Sciences, vol. 8, no. 1, pp. 1–14, 2012.
- G. A. Cordell and O. E. Araujo, “Capsaicin: identification, nomenclature, and pharmacotherapy,” The Annals of Pharmacotherapy, vol. 27, no. 3, pp. 330–336, 1993.
- D. G. Barceloux, “Pepper and capsaicin (Capsicum and Piper species),” Disease-a-Month, vol. 55, no. 6, pp. 380–390, 2009.
- M. J. Caterina, M. A. Schumacher, M. Tominaga, T. A. Rosen, J. D. Levine, and D. Julius, “The capsaicin receptor: a heat-activated ion channel in the pain pathway,” Nature, vol. 389, no. 6653, pp. 816–824, 1997.
- Y. J. Surh, “More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide,” Journal of the National Cancer Institute, vol. 94, no. 17, pp. 1263–1265, 2002.
- A. M. Sanchez, M. G. Sanchez, S. Malagarie-Cazenave, N. Olea, and I. Diaz-Laviada, “Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin,” Apoptosis, vol. 11, no. 1, pp. 89–99, 2006.
- J. Y. Kim, E. H. Kim, S. U. Kim, T. K. Kwon, and K. S. Choi, “Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation,” Carcinogenesis, vol. 31, no. 3, pp. 367–375, 2010.
- K. Ito, T. Nakazato, K. Yamato et al., “Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species,” Cancer Research, vol. 64, no. 3, pp. 1071–1078, 2004.
- Z. H. Wang, H. Chen, H. C. Guo et al., “Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo,” International Journal of Oncology, vol. 39, no. 5, pp. 1123–1131, 2011.
- V. I. Rasheva and P. M. Domingos, “Cellular responses to endoplasmic reticulum stress and apoptosis,” Apoptosis, vol. 14, no. 8, pp. 996–1007, 2009.
- P. Walter and D. Ron, “The unfolded protein response: from stress pathway to homeostatic regulation,” Science, vol. 334, no. 6059, pp. 1081–1086, 2011.
- S. Oyadomari and M. Mori, “Roles of CHOP/GADD153 in endoplasmic reticulum stress,” Cell Death and Differentiation, vol. 11, no. 4, pp. 381–389, 2004.
- L. G. Haas, “BiP (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum,” Experientia, vol. 50, no. 11-12, pp. 1012–1020, 1994.
- R. V. Rao, A. Peel, A. Logvinova et al., “Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78,” The FEBS Letters, vol. 514, no. 2-3, pp. 122–128, 2002.
- R. J. Kaufman, “Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls,” Genes & Development, vol. 13, no. 30, pp. 1211–1233, 1999.
- Q. J. Quinones, G. G. de Ridder, and S. V. Pizzo, “GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum,” Histology and Histopathology, vol. 23, no. 11, pp. 1409–1416, 2008.
- S. H. Oh and S. C. Lim, “Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells,” Journal of Pharmacology and Experimental Therapeutics, vol. 329, no. 1, pp. 112–122, 2009.
- S. W. Ip, S. H. Lan, H. F. Lu et al., “Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress,” Human and Experimental Toxicology, vol. 31, no. 6, pp. 539–549, 2012.
- R. K. Reddy, C. Mao, P. Baumeister, R. C. Austin, R. J. Kaufman, and A. S. Lee, “Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors. Role of ATP binding site in suppression of caspase-7 activation,” Journal of Biological Chemistry, vol. 278, no. 23, pp. 20915–20924, 2003.
- L. H. Zhang and X. Zhang, “Roles of GRP78 in physiology and cancer,” Journal of Cellular Biochemistry, vol. 110, no. 6, pp. 1299–1305, 2010.
- J. Lee, A. J. Bruce-Keller, Y. Kruman, S. L. Chan, and M. P. Mattson, “2-deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins,” Journal of Neuroscience Research, vol. 57, no. 1, pp. 48–61, 1999.
- R. V. Rao, H. M. Ellerby, and D. E. Bredesen, “Coupling endoplasmic reticulum stress to the cell death program,” Cell Death and Differentiation, vol. 11, no. 4, pp. 372–380, 2004.
- I. Tabas and D. Ron, “Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress,” Nature Cell Biology, vol. 13, no. 3, pp. 184–190, 2011.
- H. Zinszner, M. Kuroda, X. Wang et al., “CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum,” Genes & Development, vol. 12, no. 7, pp. 982–995, 1998.
- D. Ron and J. F. Habener, “CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription,” Genes & Development, vol. 6, no. 3, pp. 439–453, 1992.
- M. V. Barone, A. Crozat, A. Tabaee, L. Philipson, and D. Ron, “CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest,” Genes & Development, vol. 8, no. 4, pp. 453–464, 1994.
- E. Topkan, C. Parlak, A. Kotek, A. F. Yapar, and B. Pehlivan, “Predictive value of metabolic 18FDG-PET response on outcomes in patients with locally advanced pancreatic carcinoma treated with definitive concurrent chemoradiotherapy,” BMC Gastroenterology, vol. 11, article 23, 2011.
- A. F. Shields, “PET imaging of tumor growth: not as easy as it looks,” Clinical Cancer Research, vol. 18, no. 5, pp. 1189–1191, 2012.
- C. Zhao, Z. Chen, X. Ye et al., “Imaging a pancreatic carcinoma xenograft model with 11C-acetate: a comparison study with 18F-FDG,” Nuclear Medicine Communications, vol. 30, no. 12, pp. 971–977, 2009.