Xiao-Xu-Ming Decoction Protects against Blood-Brain Barrier Disruption and Neurological Injury Induced by Cerebral Ischemia and Reperfusion in Rats
Figure 5
The ultrastructural variations of the BBB 24 h after reperfusion. (a) The ultrastructure of the BBB in the sham group. Strong integrity of the basement membrane (A), a clear tight junction (B), and normal astrocyte endfeet (C) were observed. (b) The ultrastructure of the BBB in the IR group. The edema around the capillary was marked in the IR group, the astrocyte endfeet surrounding the capillaries were swollen (D), and some endfeet showed vacuolar changes. Moreover, the Golgi complex was swollen (E), the capillary lumen was shrunk (F), and the tight junction could not be observed in the images. (c) The ultrastructure of the BBB in the XXMD60 group. The edema was mitigated (H) and a regular capillary lumen, continuous base membrane, and clear tight junction (I) could be found. for each group. Scale bar = 1 μm.
