Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells

<table>Effect of resveratrol on cell viability, MMP-9 expression, and invasion capacity in B16 cells with <i>α</i>-MSH (10 nM), STI571 (20 <i>μ</i>M), and/or resveratrol (15 <i>μ</i>M) treatment. (a) Viability assay by using a trypan blue dye exclusion test. (b) MMP-9 expression by Western blotting. (c) Cell invasion assay. <svg height="13.95" id="M10" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> as compared to the control group. <sup>#</sup><svg height="11.375" id="M11" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> as compared between <i>α</i>-MSH treatment and untreated group. Res: resveratrol; STI: STI571. </table>

Evidence-Based Complementary and Alternative Medicine

fig5

Figure 5

Figure 5: Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells 