Curcumin and Diabetes: A Systematic Review

Table 2

The applications of curcuminoids in treating diabetes and its associated disorders.

Curcuminoids	Structures	Antidiabetic function	Reference
NCD	PCT/; EG2010/000008*	Decreasing lipid peroxides; attenuating mitochondria dysfunction	[164]
Demethoxycurcumin (DMC)		Induction of HO; elevating levels of glutamyl cysteine ligase and NAD(P)H:quinone oxidoreductase; inactivating pancreatic a-amylase	[166, 167]
Bisdemethoxycurcumin (BDMC)
Tetrahydrocurcumin (THC)		Scavenging ROS; modulating hepatic metabolism enzyme and antioxidant enzyme; decreasing level of glycoprotein; normalizing erythrocyte membrane bounding enzyme and renal abnormalities.	[14, 16, 35, 168–178]
Bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione		Deceasing ALP, LDH, TGA, FFA, and tissue phospholipids; elevating levels of SOD, CAT, and GPx.	[179–181]
Bis-o-hydroxycinnamoyl methane		Scavenging ROS and protecting the pancreatic 𝛽-cell
Bis(curcumino)oxovanadium complex		Decreasing blood glucose levels and serum lipids; restoring blood pressure and vascular reactivity	[182]
C66		Reducing production of TNF-𝛼 and NO; inhibiting mRNA levels of IL-1𝛽, TNF-𝛼, IL-6, IL-12, COX-2, and iNOS; inhibiting activation of JNK/NF-𝜅B signaling	[183, 184]
B06

∗Published patent pending, WO 2011/100984.