Ginsenoside Rh2 Downregulates LPS-Induced NF-κB Activation through Inhibition of TAK1 Phosphorylation in RAW 264.7 Murine Macrophage

Figure 7

A proposed pathway scheme of ginsenoside Rh2 on LPS-primed RAW 264.7 murine macrophages. Ginsenoside Rh2 inhibits upstream signal TLR4/CD14 expressions and regulates TAK1 phosphorylation, eventually blocking NF-κB activation. Meanwhile, ginsenoside Rh2 suppressed LPS-induced HIF-1α accumulation at least partially dependent on NF-κB activation. This study indicates that ginsenoside Rh2 effectively modulates the regulation of NF-κB via TAK1 in RAW 264.7 murine macrophages.