A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
Table 2
Identified markers between healthy control and HFMD.
Mode
R.T (min)
Exact mass
Formula
Compound (Resource)
Significance/fold change
G2 versus G1
G3 versus G2
G3 versus G1
1.8
145.1103
C7H15NO2
Acetylcholine (HMDB)
**/ 1.48
**/ 0.65
**/ 0.77
2.5
202.1205
C10H18O4
Sebacic acid (HMDB)
**/ 1.58
**/ 0.67
N.S
2.6
90.0317
C3H6O3
Lactic acid (HMDB)
**/ 13.4
N.S
**/ 13.4
3.6
258.0141
C6H11O9P
2-Keto-3-deoxy-6-phosphogluconic acid (HMDB)
**/ 5.55
**/ 0.12
N.S
3.7
247.0246
C8H10NO6P
Pyridoxal phosphate (HMDB)
**/ 5.23
**/ 0.31
N.S
6.0
219.1107
C9H17NO5
D-Pantothenic acid (HMDB)
**/ 0.47
**/ 2.28
N.S
6.2
138.0429
C6H6N2O2
Urocanic acid (HMDB)
**/ ∞
N.S
**/ ∞
ESI (+)
10.1
180.0634
C6H12O6
beta-D-Glucose (HMDB)
**/ 0.38
N.S
**/ 0.37
13.7
519.3325
C26H50NO7P
1-18:2(9Z,12Z) Lysophosphatidylcholine (HMDB)
**/ 0.49
**/ 1.84
N.S
12.71
169.0504
C4H12NO4P
Phosphorylcholine (HMDB)
**/ 0.13
**/ 5.98
N.S
12.72
250.1205
C14H18O4
Ubiquinone (HMDB)
**/ 0.27
**/ 0.22
**/ 0.06
14.1
671.489
C37H70NO7P
Phosphatidylethanolamine (KEGG)
**/ 0
N.S
**/ 0
14.3
714.5223
C47H70O5
Diacylglycerol (HMDB)
**/ 0
N.S
**/ 0
14.7
571.3638
C30H54NO7P
1-Acyl-sn-glycerol-3-phosphocholine (HMDB)
**/ 2.02
*/ 0.88
*/ 1.78
16.4
103.0997
C5H13NO
Choline (HMDB)
**/ 1.69
**/ 0.69
*/ 1.17
17.8
522.3604
C28H50N4O3S
Oleic acid (HMDB)
**/ 0
N.S
**/ 0
1.5
146.1055
C6H14N2O2
L-Lysine (HMDB)
**/ 1.56
**/ 1.48
**/ 2.02
1.6
336.0484
C11H15NO9P
Nicotinate D-ribonucleotide (HMDB)
**/ 2.58
N.S
**/ 2.73
1.8
131.0695
C4H9N3O2
Creatine (HMDB)
**/ 0.43
**/ 2.08
N.S
2.1
119.0582
C4H9NO3
L-Threonine (HMDB)
**/ 0.46
**/ 2.07
N.S
4.28
366.0577
C10H15N4O9P
FAICAR (ChemSpider)
**/ 16.24
**/ 0.04
N.S
4.29
104.0473
C4H8O3
(S)-3-Hydroxy-2-methylpropanoic acid (HMDB)
**/ 1.77
**/ 0.54
N.S
5.4
165.0426
C8H7NO3
2-(Formylamino)-benzoic acid (HMDB)
*/ 2.08
**/ 0.35
N.S
5.6
180.0786
C10H12O3
Coniferyl alcohol (HMDB)
**/ ∞
**/ 0
N.S
ESI (−)
6.5
258.1106
C8H21NO6P
sn-glycero-3-Phosphocholine (HMDB)
**/ 0.26
*/ 7.93
N.S
8.0
248.1161
C13H16N2O3
6-Hydroxymelatonin (ChemSpider)
**/ 0.18
*/ 4.25
N.S
10.0
276.1321
C11H20N2O6
Saccharopine (HMDB)
**/ ∞
**/ 0.24
**/ ∞
10.8
324.0359
C9H13N2O9P
Pseudouridylic acid (ChemSpider)
**/ ∞
**/ 0
N.S
12.8
308.041
C9H13N2O8P
dUMP (HMDB)
**/ 26.7
**/ 0.1
*/ 46.8
15.0
364.2613
C22H36O4
Prostaglandin E2 (HMDB)
**/ 2.10
N.S
**/ 1.83
16.6
226.1933
C14H26O2
9Z-Tetradecenoic acid (HMDB)
**/ 0.49
N.S
**/ 0.47
G1: healthy control group; G2: HFMD group; G3: combination therapy group; HMDB: Human Metabolome Database; KEGG: Kyoto Encyclopedia of Genes and Genomes. (: represented denominator is zero; P < 0.05; P < 0.01; N.S: no significance).
