Increased Nerve Growth Factor Signaling in Sensory Neurons of Early Diabetic Rats Is Corrected by Electroacupuncture
Figure 4
Low and high magnification confocal microscopy images of TrkA and double immunofluorescence in the spinal cord of STZ, STZ + EA, and Control groups. In all three groups, TrkA and immunoreactivity appeared mainly expressed in the superficial dorsal horn and surrounding white matter as terminals and small fibers. An intense immunoreactivity was observed in bundles of fibers running tangentially to the superficial dorsal horn in the white matter. In the same region, a medium intensity TrkA immunoreactivity was present in wisps of small fibers running radially to the superficial dorsal horn. In the laminae I and II of the dorsal horn, both TrkA and immunoreactivity appeared as positive terminals or small fibers which very often showed juxtaposition relations but not colocalization. Scale bar: 15 μm.
